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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Lysyl-tRNA synthetase 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Lysyl-tRNA synthetase 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q15046 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6130 |
| Calculated MW | Predicted, 68 kDa, observed, 73 kDa |
| Gene Name | KARS1 |
| Aliases | KARS1; Lysyl-TRNA Synthetase 1; KARS2; KARS; Lysyl-TRNA Synthetase; Lysine--TRNA Ligase; Lysine TRNA Ligase; EC 6.1.1.6; DFNB89; LysRS; Deafness, Autosomal Recessive 89; EC 2.7.7.-; KIAA0070; EC 6.1.1; CMTRIB; DEAPLE; LEPID; KRS |
| Immunogen | A synthesized peptide derived from human LysRS |
| Gene ID | 3735 |
|---|---|
| Other Names | Lysine--tRNA ligase, 2.7.7.-, 6.1.1.6, Lysyl-tRNA synthetase, LysRS, KARS1 (HGNC:6215), KARS, KIAA0070 |
| Name | KARS1 (HGNC:6215) |
|---|---|
| Synonyms | KARS, KIAA0070 |
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). |
| Cellular Location | [Isoform Cytoplasmic]: Cytoplasm, cytosol. Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted Note=Secretion is induced by TNF-alpha (PubMed:15851690). Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E (PubMed:23159739) |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1074
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