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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody
KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P12268 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6135 |
| Calculated MW | Predicted, 56 kDa, observed, 56 kDa |
| Gene Name | IMPDH2 |
| Aliases | IMPDH2; Inosine Monophosphate Dehydrogenase 2; IMP (Inosine 5'-Monophosphate) Dehydrogenase 2; Inosine-5'-Monophosphate Dehydrogenase Type II; Inosine-5'-Monophosphate Dehydrogenase 2; IMP Dehydrogenase II; EC 1.1.1.205; IMPDH-II; IMPDH 2; IMPD 2; IMPD2; IMP (Inosine Monophosphate) Dehydrogenase 2; Inosine Monophosphate Dehydrogenase Type II; Epididymis Secretory Sperm Binding Protein; Inosine 5' Phosphate Dehydrogenase 2; IMP Dehydrogenase 2; IMP Oxireductase 2 |
| Immunogen | A synthesized peptide derived from human IMPDH2 |
| Gene ID | 3615 |
|---|---|
| Other Names | Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2, IMPD 2, IMPDH 2, 1.1.1.205, Inosine-5'-monophosphate dehydrogenase type II, IMP dehydrogenase II, IMPDH-II, IMPDH2 (HGNC:6053), IMPD2 |
| Name | IMPDH2 (HGNC:6053) |
|---|---|
| Synonyms | IMPD2 |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion. |
| Tissue Location | IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1076
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