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KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
  • WB - KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody AGI1076
    Western blotting analysis using anti-IMPDH2 antibody (Cat#61198). Total cell lysates (30 µg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-IMPDH2 antibody (Cat#61198, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716).
    detail
  • WB - KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody AGI1076
    Western blotting analysis using anti-IMPDH2 antibody (Cat#61198). IMPDH2 expression in wild type (WT) and IMPDH2 shRNA knockdown (KD) HeLa cells with 20 µg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-IMPDH2 antibody (Cat#61198, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716).
    detail
  • FC - KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody AGI1076
    Flow cytometric analysis of IMPDH2 expression in HT-1080 cells using IMPDH2 antibody (Cat#61198, 1:2,000). Green, isotype control; red, IMPDH2.
    detail
  • ICC - KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody AGI1076
    Immunocytochemical staining of HT-1080 cells with anti-IMPDH2 antibody (Cat#61198, 1:1,000). Nuclei were stained blue with DAPI; IMPDH2 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 µm.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, ICC
Primary Accession P12268
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 24GB6135
Calculated MW Predicted, 56 kDa, observed, 56 kDa
Gene Name IMPDH2
Aliases IMPDH2; Inosine Monophosphate Dehydrogenase 2; IMP (Inosine 5'-Monophosphate) Dehydrogenase 2; Inosine-5'-Monophosphate Dehydrogenase Type II; Inosine-5'-Monophosphate Dehydrogenase 2; IMP Dehydrogenase II; EC 1.1.1.205; IMPDH-II; IMPDH 2; IMPD 2; IMPD2; IMP (Inosine Monophosphate) Dehydrogenase 2; Inosine Monophosphate Dehydrogenase Type II; Epididymis Secretory Sperm Binding Protein; Inosine 5' Phosphate Dehydrogenase 2; IMP Dehydrogenase 2; IMP Oxireductase 2
Immunogen A synthesized peptide derived from human IMPDH2
Additional Information
Gene ID 3615
Other Names Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2, IMPD 2, IMPDH 2, 1.1.1.205, Inosine-5'-monophosphate dehydrogenase type II, IMP dehydrogenase II, IMPDH-II, IMPDH2 (HGNC:6053), IMPD2
Protein Information
Name IMPDH2 (HGNC:6053)
Synonyms IMPD2
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion.
Tissue Location IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1076
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