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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-VAMP8 Rabbit Monoclonal Antibody
KD-Validated Anti-VAMP8 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9BV40 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB590 |
| Calculated MW | Predicted, 11 kDa; observed, 16kDa |
| Gene Name | VAMP8 |
| Aliases | VAMP8; Vesicle Associated Membrane Protein 8; VAMP-8; EDB; Vesicle-Associated Membrane Protein 8; Endobrevin; Vesicle-Associated Membrane Protein 8 (Endobrevin) |
| Immunogen | A synthesized peptide derived from human VAMP8 |
| Gene ID | 8673 |
|---|---|
| Other Names | Vesicle-associated membrane protein 8, VAMP-8, Endobrevin, EDB, VAMP8 {ECO:0000303|PubMed:12130530} |
| Name | VAMP8 {ECO:0000303|PubMed:12130530} |
|---|---|
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946). |
| Cellular Location | Lysosome membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Cell membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein. Zymogen granule membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity) Sub-tight junctional domain in retinal pigment epithelium cells Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity) {ECO:0000250|UniProtKB:Q9WUF4} |
| Tissue Location | Platelets.. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1109
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