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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-F-Box Protein 11 Mouse Monoclonal Antibody
KD-Validated Anti-F-Box Protein 11 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q86XK2 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 25GB520 |
| Calculated MW | Predicted, 104 kDa, observed, 120 kDa |
| Gene Name | FBXO11 |
| Aliases | FBXO11; F-Box Protein 11; FBX11; F-Box Only Protein 11; UBR6; Ubiquitin Protein Ligase E3 Component N-Recognin 6; Protein Arginine N-Methyltransferase 9; Vitiligo-Associated Protein 1; PRMT9; VIT1; Vitiligo-Associated Protein VIT-1; UG063H01; IDDFBA; VIT-1 |
| Immunogen | Recombinant protein of human FBXO11 |
| Gene ID | 80204 |
|---|---|
| Other Names | F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11 {ECO:0000303|PubMed:25827072, ECO:0000312|HGNC:HGNC:13590} |
| Name | FBXO11 {ECO:0000303|PubMed:25827072, ECO:0000312|HGNC:HGNC:13590} |
|---|---|
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B- cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010). |
| Cellular Location | Nucleus. Chromosome |
| Tissue Location | Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1116
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