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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CC2D1A Rabbit Monoclonal Antibody
KD-Validated Anti-CC2D1A Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q6P1N0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3045 |
| Calculated MW | Predicted, 104 kDa , observed, 130 kDa |
| Gene Name | CC2D1A |
| Aliases | CC2D1A; Coiled-Coil And C2 Domain Containing 1A; Five Prime Repressor Element Under Dual; Repression-Binding Protein 1; Akt Kinase-Interacting Protein 1; MRT3; TAPE; Coiled-Coil And C2 Domain-Containing Protein 1A; FRE Under Dual Repression-Binding Protein 1; Putative NF-Kappa-B-Activating Protein 023N; TBK1-Associated Protein In Endolysosomes 2; Lethal (2) Giant Discs Homolog 2; FLJ20241; Freud-1; FREUD-1; Aki-1; Lgd2; Five Repressor Element Under Dual Repression-Binding Protein 1; Mental Retardation, Nonsyndromic, Autosomal Recessive, 3; Putative NFkB Activating Protein; Freud-1/Aki1; AKI-1; LGD2; AKI1 |
| Immunogen | A synthesized peptide derived from CC2D1A |
| Gene ID | 54862 |
|---|---|
| Other Names | Coiled-coil and C2 domain-containing protein 1A, Akt kinase-interacting protein 1, Five prime repressor element under dual repression-binding protein 1, FRE under dual repression-binding protein 1, Freud-1, Putative NF-kappa-B-activating protein 023N, CC2D1A, AKI1, LGD2 {ECO:0000305} |
| Name | CC2D1A |
|---|---|
| Synonyms | AKI1, LGD2 {ECO:0000305} |
| Function | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q66HA5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1147
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