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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Catenin alpha 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Catenin alpha 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P35221 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3335 |
| Calculated MW | Predicted, 100 kDa , observed, 100 kDa |
| Gene Name | CTNNA1 |
| Aliases | CTNNA1; Catenin Alpha 1; CAP102; Renal Carcinoma Antigen NY-REN-13; Alpha-E-Catenin; Catenin Alpha-1; Catenin (Cadherin-Associated Protein), Alpha 1 (102kD); Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa; Epididymis Secretory Sperm Binding Protein; Cadherin-Associated Protein; Alpha E-Catenin; MDBS2; MDPT2 |
| Immunogen | A synthesized peptide derived from human alpha 1 Catenin |
| Gene ID | 1495 |
|---|---|
| Other Names | Catenin alpha-1 {ECO:0000312|HGNC:HGNC:2509}, Alpha E-catenin {ECO:0000312|HGNC:HGNC:2509}, Cadherin-associated protein {ECO:0000312|HGNC:HGNC:2509}, Renal carcinoma antigen NY-REN-13, CTNNA1 (HGNC:2509) |
| Name | CTNNA1 (HGNC:2509) |
|---|---|
| Function | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1- dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P26231}. Cell junction, adherens junction. Cell membrane {ECO:0000250|UniProtKB:P26231}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:P26231}. Cell junction Cytoplasm {ECO:0000250|UniProtKB:Q9PVF8}. Nucleus. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. {ECO:0000250|UniProtKB:P26231} |
| Tissue Location | [Isoform 1]: Ubiquitously expressed in normal tissues. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1177
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