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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-ATP2A2 Rabbit Monoclonal Antibody
KD-Validated Anti-ATP2A2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P16615 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3250 |
| Calculated MW | Predicted, 115 kDa, observed, 110 kDa |
| Gene Name | ATP2A2 |
| Aliases | ATP2A2; ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2; SERCA2; Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2; Calcium Pump 2; ATP2B; Endoplasmic Reticulum Class 1/2 Ca(2+) ATPase; SR Ca(2+)-ATPase; DAR; Calcium-Transporting ATPase Sarcoplasmic Reticulum Type, Slow Twitch Skeletal Muscle Isoform; ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2; ATPase Ca++ Transporting Cardiac Muscle Slow Twitch 2; ATPase, Ca++ Dependent, Slow-Twitch, Cardiac Muscle-2; Cardiac Ca2+ ATPase; EC 7.2.2.10; EC 3.6.3.8; EC 3.6.3; DD |
| Immunogen | A synthesized peptide derived from human SERCA2 |
| Gene ID | 488 |
|---|---|
| Other Names | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2, SR Ca(2+)-ATPase 2, 7.2.2.10, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, ATP2A2 (HGNC:812), ATP2B |
| Name | ATP2A2 (HGNC:812) |
|---|---|
| Synonyms | ATP2B |
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O55143}; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with FLVCR2 at the mitochondrial-ER contact junction. {ECO:0000250|UniProtKB:O55143} |
| Tissue Location | Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1191
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