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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CSE1L Rabbit Monoclonal Antibody
KD-Validated Anti-CSE1L Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P55060 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3515 |
| Calculated MW | Predicted, 110 kDa , observed, 98 kDa |
| Gene Name | CSE1L |
| Aliases | CSE1L; Chromosome Segregation 1 Like; XPO2; CAS; CSE1; Cellular Apoptosis Susceptibility Protein; Chromosome Segregation 1-Like Protein; Importin-Alpha Re-Exporter; Exportin-2; Exp2; Chromosome Segregation 1 (Yeast Homolog)-Like; CSE1 Chromosome Segregation 1-Like (Yeast); Epididymis Secretory Sperm Binding Protein; CSE1 Chromosome Segregation 1 Like; CSE1 Chromosome Segregation 1-Like; Cellular Apoptosis Susceptibility |
| Immunogen | A synthesized peptide derived from human Exportin2 |
| Gene ID | 1434 |
|---|---|
| Other Names | Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CAS {ECO:0000303|PubMed:7479798}, XPO2 |
| Name | CSE1L |
|---|---|
| Synonyms | CAS {ECO:0000303|PubMed:7479798}, XPO2 |
| Function | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Cellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. |
| Tissue Location | Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:10331944, PubMed:7479798). |
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$ 149.00
$ 499.00
Cat# AGI1208
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