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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Histone deacetylase 8 Rabbit Monoclonal Antibody
KD-Validated Anti-Histone deacetylase 8 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9BY41 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB2495 |
| Calculated MW | Predicted, 42 kDa; observed, 42 kDa |
| Gene Name | HDAC8 |
| Aliases | HDAC8; Histone Deacetylase 8; HDACL1; KDAC8; RPD3; Protein Decrotonylase HDAC8; Histone Deacetylase-Like 1; Protein Deacetylase HDAC8; MRXS6; HD8; WTS; Wilson-Turner X-Linked Mental Retardation Syndrome; EC 3.5.1.98; EC 3.5.1.-; CDA07; CDLS5 |
| Immunogen | A synthesized peptide derived from human PKM2 |
| Gene ID | 55869 |
|---|---|
| Other Names | Histone deacetylase 8, HD8, 3.5.1.98, Protein deacetylase HDAC8, 3.5.1.-, Protein decrotonylase HDAC8, 3.5.1.-, HDAC8 {ECO:0000303|PubMed:10926844, ECO:0000312|HGNC:HGNC:13315} |
| Name | HDAC8 {ECO:0000303|PubMed:10926844, ECO:0000312|HGNC:HGNC:13315} |
|---|---|
| Function | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin (PubMed:22885700). May play a role in smooth muscle cell contractility (PubMed:15772115). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810). |
| Cellular Location | Nucleus. Chromosome Cytoplasm Note=Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051). |
| Tissue Location | Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1211
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