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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-ABCE1 Rabbit Monoclonal Antibody
KD-Validated Anti-ABCE1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P61221 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3605 |
| Calculated MW | Predicted, 67 kDa , observed, 67 kDa |
| Gene Name | ABCE1 |
| Aliases | ABCE1; ATP Binding Cassette Subfamily E Member 1; RLI; RNASEL1; RNASELI; RNS4I; OABP; RLI1; ATP-Binding Cassette, Sub-Family E (OABP), Member 1; ATP-Binding Cassette Sub-Family E Member 1; 2'-5'-Oligoadenylate-Binding Protein; Ribonuclease 4 Inhibitor; RNase L Inhibitor 1; HuHP68; Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) Inhibitor; RNase L Inhibitor; EC 3.6.5.-; ABC38 |
| Immunogen | A synthesized peptide derived from human ABCE1 |
| Gene ID | 6059 |
|---|---|
| Other Names | ATP-binding cassette sub-family E member 1, 3.6.5.-, 2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, ABCE1, RLI, RNASEL1, RNASELI, RNS4I |
| Name | ABCE1 |
|---|---|
| Synonyms | RLI, RNASEL1, RNASELI, RNS4I |
| Function | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane- localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). |
| Cellular Location | Cytoplasm. Mitochondrion |
Research Areas
Citations (0)
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1214
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