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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Dihydrolipoamide dehydrogenase Rabbit Monoclonal Antibody
KD-Validated Anti-Dihydrolipoamide dehydrogenase Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P09622 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3825 |
| Calculated MW | Predicted, 54 kDa , observed, 56 kDa |
| Gene Name | DLD |
| Aliases | DLD; Dihydrolipoamide Dehydrogenase; OGDC-E3; DLDH; GCSL; LAD; E3; E3 Component Of Pyruvate Dehydrogenase Complex, 2-Oxo-Glutarate Complex, Branched Chain Keto Acid Dehydrogenase Complex; Dihydrolipoyl Dehydrogenase, Mitochondrial; Glycine Cleavage System L Protein; EC 1.8.1.4; PHE3; Dihydrolipoamide Dehydrogenase (E3 Component Of Pyruvate Dehydrogenase Complex, 2-Oxo-Glutarate Complex, Branched Chain Keto Acid Dehydrogenase Complex); Epididymis Secretory Sperm Binding Protein; Glycine Cleavage System Protein L; Lipoamide Dehydrogenase; Lipoyl Dehydrogenase; Lipoamide Reductase; Diaphorase; EC 1.8.1 48; DLDD |
| Immunogen | A synthesized peptide derived from human DLDH |
| Gene ID | 1738 |
|---|---|
| Other Names | Dihydrolipoyl dehydrogenase, mitochondrial, 1.8.1.4, Dihydrolipoamide dehydrogenase, Glycine cleavage system L protein, DLD, GCSL, LAD, PHE3 |
| Name | DLD |
|---|---|
| Synonyms | GCSL, LAD, PHE3 |
| Function | Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2- oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). |
| Cellular Location | Mitochondrion matrix. Nucleus. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation. |
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$ 149.00
$ 499.00
Cat# AGI1232
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