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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Hsp60 Rabbit Monoclonal Antibody
KD-Validated Anti-Hsp60 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P10809 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB2680 |
| Calculated MW | Predicted, 61 kDa , observed, 60 kDa |
| Gene Name | HSPD1 |
| Aliases | HSPD1; Heat Shock Protein Family D (Hsp60) Member 1; HSP60; 60 KDa Heat Shock Protein, Mitochondrial; Heat Shock 60kDa Protein 1 (Chaperonin); Mitochondrial Matrix Protein P1; P60 Lymphocyte Protein; 60 KDa Chaperonin; Chaperonin 60; HuCHA60; HSP-60; CPN60; GROEL; SPG13; Spastic Paraplegia 13 (Autosomal Dominant); Epididymis Secretory Sperm Binding Protein; Heat Shock 60kD Protein 1 (Chaperonin); Short Heat Shock Protein 60 Hsp60s1; Heat Shock Protein 65; Heat Shock Protein 60; EC 5.6.1.7; GroEL; HSP65; Hsp60; HLD4 |
| Immunogen | A synthesized peptide derived from human Hsp60 |
| Gene ID | 3329 |
|---|---|
| Other Names | 60 kDa heat shock protein, mitochondrial, 5.6.1.7, 60 kDa chaperonin, Chaperonin 60, CPN60, Heat shock protein 60, HSP-60, Hsp60, Heat shock protein family D member 1, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein, HSPD1, HSP60 |
| Name | HSPD1 |
|---|---|
| Synonyms | HSP60 |
| Function | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back- to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). |
| Cellular Location | Mitochondrion matrix. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1245
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