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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-LDL receptor related protein 8 Rabbit Monoclonal Antibody
KD-Validated Anti-LDL receptor related protein 8 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q14114 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2520 |
| Calculated MW | Predicted, 106 kDa , observed, 106 kDa |
| Gene Name | LRP8 |
| Aliases | LRP8; LDL Receptor Related Protein 8; APOER2; LRP-8; HSZ75190; MCI1; Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor; Low-Density Lipoprotein Receptor-Related Protein 8; Apolipoprotein E Receptor 2; ApoE Receptor 2 |
| Immunogen | A synthesized peptide derived from human ApoER2 |
| Gene ID | 7804 |
|---|---|
| Other Names | Low-density lipoprotein receptor-related protein 8, LRP-8, Apolipoprotein E receptor 2, LRP8, APOER2 |
| Name | LRP8 |
|---|---|
| Synonyms | APOER2 |
| Function | Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands (PubMed:12899622, PubMed:12950167, PubMed:20223215, PubMed:30873003). LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail (By similarity). Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons (By similarity). LRP8 has higher affinity for Reelin than VLDLR (By similarity). LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development (By similarity). Binds the endoplasmic reticulum resident receptor- associated protein (RAP) (By similarity). Binds dimers of beta 2- glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature (PubMed:12807892). Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation (By similarity). May also function as an endocytic receptor (By similarity). Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid- derived suppressor cells (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Secreted {ECO:0000250|UniProtKB:Q924X6}. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment {ECO:0000250|UniProtKB:Q924X6} |
| Tissue Location | Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1250
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