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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-NEK7 Rabbit Monoclonal Antibody
KD-Validated Anti-NEK7 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q8TDX7 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2885 |
| Calculated MW | Predicted, 35 kDa , observed, 35 kDa |
| Gene Name | NEK7 |
| Aliases | NIMA Related Kinase 7; NIMA (Never In Mitosis Gene A)-Related Kinase 7; Serine/Threonine-Protein Kinase Nek7; Never In Mitosis A-Related Kinase 7; NimA-Related Protein Kinase 7; EC 2.7.11.34; EC 2.7.11.1 |
| Immunogen | A synthesized peptide derived from human NEK7 |
| Gene ID | 140609 |
|---|---|
| Other Names | Serine/threonine-protein kinase Nek7, 2.7.11.34, Never in mitosis A-related kinase 7, NimA-related protein kinase 7, NEK7 {ECO:0000303|PubMed:11701951, ECO:0000312|HGNC:HGNC:13386} |
| Name | NEK7 {ECO:0000303|PubMed:11701951, ECO:0000312|HGNC:HGNC:13386} |
|---|---|
| Function | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:19941817, PubMed:26522158, PubMed:31409757). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502, PubMed:39173637). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502, PubMed:39173637). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9ES74}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9ES74, ECO:0000269|PubMed:17586473} |
| Tissue Location | Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1261
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