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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Protein arginine methyltransferase 7 Rabbit Monoclonal Antibody
KD-Validated Anti-Protein arginine methyltransferase 7 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9NVM4 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2380 |
| Calculated MW | Predicted, 78 kDa, observed, 75 kDa |
| Gene Name | PRMT7 |
| Aliases | PRMT7; Protein Arginine Methyltransferase 7; KIAA1933; [Myelin Basic Protein]-Arginine N-Methyltransferase PRMT7; Histone-Arginine N-Methyltransferase PRMT7; Protein Arginine N-Methyltransferase 7; FLJ10640; EC 2.1.1.321; EC 2.1.1 48; SBIDDS |
| Immunogen | A synthesized peptide derived from human PRMT7 |
| Gene ID | 54496 |
|---|---|
| Other Names | Protein arginine N-methyltransferase 7, 2.1.1.321, Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7, PRMT7, KIAA1933 |
| Name | PRMT7 |
|---|---|
| Synonyms | KIAA1933 |
| Function | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1273
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