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KD-Validated Anti-Syntaxin binding protein 1 Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
  • WB - KD-Validated Anti-Syntaxin binding protein 1 Rabbit Monoclonal Antibody AGI1286
    Western blotting analysis using anti-Syntaxin binding protein 1 antibody (Cat#61518). Total cell lysates (30 µg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-Syntaxin binding protein 1 antibody (Cat#61518, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226).
    detail
  • WB - KD-Validated Anti-Syntaxin binding protein 1 Rabbit Monoclonal Antibody AGI1286
    Western blotting analysis using anti-Syntaxin binding protein 1 antibody (Cat#61518). Syntaxin binding protein 1 expression in wild type (WT) and syntaxin binding protein 1 shRNA knockdown (KD) HeLa cells with 30 µg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with anti-Syntaxin binding protein 1 antibody (Cat#61518, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226).
    detail
  • FC - KD-Validated Anti-Syntaxin binding protein 1 Rabbit Monoclonal Antibody AGI1286
    Flow cytometric analysis of Syntaxin binding protein 1 expression in C2C12 cells using Syntaxin binding protein 1 antibody (Cat#61518, 1:2,000). Green, isotype control; red, Syntaxin binding protein 1.
    detail
  • ICC - KD-Validated Anti-Syntaxin binding protein 1 Rabbit Monoclonal Antibody AGI1286
    Immunocytochemical staining of C2C12 cells with Syntaxin binding protein 1 antibody (Cat#61518, 1:1,000). Nuclei were stained blue with DAPI; Syntaxin binding protein 1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 µm.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, ICC
Primary Accession P61764
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 23GB 2570
Calculated MW Predicted, 68 kDa , observed, 68 kDa
Gene Name STXBP1
Aliases STXBP1; Syntaxin Binding Protein 1; MUNC18-1; Syntaxin-Binding Protein 1; UNC18; Protein Unc-18 Homolog 1; Protein Unc-18 Homolog A; Unc-18A; Unc18-1; HUNC18; N-Sec1; RBSEC1; NSEC1; P67; Neuronal SEC1; RbSec1; UNC18A; NSec1; DEE4
Immunogen A synthesized peptide derived from human STXBP1
Additional Information
Gene ID 6812
Other Names Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A
Protein Information
Name STXBP1
Synonyms UNC18A
Function Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions.
Cellular Location Cytoplasm, cytosol. Membrane; Peripheral membrane protein
Tissue Location Brain and spinal cord. Highly enriched in axons.
Research Areas
Citations (0)
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$ 149.00
$ 499.00
Cat# AGI1286
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