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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-TEAD1 Rabbit Monoclonal Antibody
KD-Validated Anti-TEAD1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P28347 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2795 |
| Calculated MW | Predicted, 48 kDa , observed, 52 kDa |
| Gene Name | TEAD1 |
| Aliases | TEAD1; TEA Domain Transcription Factor 1; TEF-1; TCF13; TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor); Transcriptional Enhancer Factor TEF-1; Transcriptional Enhancer Factor 1; Transcription Factor 13; Protein GT-IIC; NTEF-1; TCF-13; TEAD-1; AA; Atrophia Areata, Peripapillary Chorioretinal Degeneration; TEA Domain Family Member 1; REF1; TEF1 |
| Immunogen | A synthesized peptide derived from human TEAD1 |
| Gene ID | 7003 |
|---|---|
| Other Names | Transcriptional enhancer factor TEF-1, NTEF-1, Protein GT-IIC, TEA domain family member 1, TEAD-1, Transcription factor 13, TCF-13, TEAD1, TCF13, TEF1 |
| Name | TEAD1 |
|---|---|
| Synonyms | TCF13, TEF1 |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. |
| Cellular Location | Nucleus. |
| Tissue Location | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1289
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