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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-ARPC2 Rabbit Monoclonal Antibody
KD-Validated Anti-ARPC2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O15144 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2985 |
| Calculated MW | Predicted, 34 kDa , observed, 34 kDa |
| Gene Name | ARPC2 |
| Aliases | Actin Related Protein 2/3 Complex Subunit 2;ARC34;P34-Arc;Actin-Related Protein 2/3 Complex Subunit;Arp2/3 Complex 34 KDa Subunit;Actin Related Protein 2/3 Complex, Subunit 2 (34 KD) ;Actin Related Protein 2/3 Complex, Subunit 2, 34kDa ;Actin Related Protein 2/3 Complex Subunit 2, 34kDa ;Testis Tissue Sperm-Binding Protein Li 53e ;ARP2/3 Protein Complex Subunit 34 ;PNAS-139 ;PRO2446;P34-ARC |
| Immunogen | A synthesized peptide derived from human ARPC2 |
| Gene ID | 10109 |
|---|---|
| Other Names | Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC, ARPC2, ARC34 |
| Name | ARPC2 |
|---|---|
| Synonyms | ARC34 |
| Function | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1306
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