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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CLP1 Rabbit Monoclonal Antibody
KD-Validated Anti-CLP1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q92989 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3085 |
| Calculated MW | Predicted, 48 kDa , observed, 48 kDa |
| Gene Name | CLP1 |
| Aliases | CLP1; Cleavage Factor Polyribonucleotide Kinase Subunit 1; HEAB; Cleavage And Polyadenylation Factor I Subunit 1; Polyribonucleotide 5'-Hydroxyl-Kinase Clp1; Pre-MRNA Cleavage Complex II Protein Clp1; Polyadenylation Factor Clp1; Polynucleotide Kinase Clp1; EC 2.7.1.78; HClp1; CLP1, Cleavage And Polyadenylation Factor I Subunit, Homolog (S. Cerevisiae); Polyribonucleotide 5'-Hydroxyl-Kinase; Homolog Of Yeast CFIA Subunit Clp1p; ATP/GTP-Binding Protein; ATP/GTPbinding Protein; HCLP1 |
| Immunogen | A synthesized peptide derived from human HEAB |
| Gene ID | 10978 |
|---|---|
| Other Names | Polyribonucleotide 5'-hydroxyl-kinase Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, 2.7.1.78 {ECO:0000255|HAMAP-Rule:MF_03035}, Polyadenylation factor Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, Polynucleotide kinase Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, Pre-mRNA cleavage complex II protein Clp1 {ECO:0000255|HAMAP-Rule:MF_03035}, CLP1 {ECO:0000255|HAMAP-Rule:MF_03035}, HEAB |
| Name | CLP1 {ECO:0000255|HAMAP-Rule:MF_03035} |
|---|---|
| Synonyms | HEAB |
| Function | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03035, ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:24766810} |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1307
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