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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-MELK Rabbit Monoclonal Antibody
KD-Validated Anti-MELK Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q14680 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3005 |
| Calculated MW | Predicted, 75 kDa; observed, 70 kDa |
| Gene Name | MELK |
| Aliases | MELK; Maternal Embryonic Leucine Zipper Kinase; KIAA0175; Tyrosine-Protein Kinase MELK; Protein Kinase PK38; Protein Kinase Eg3; PEg3 Kinase; EC 2.7.11.1; HPK38; EC 2.7.10.2; EC 2.7.11; HMELK |
| Immunogen | A synthesized peptide derived from human MELK |
| Gene ID | 9833 |
|---|---|
| Other Names | Maternal embryonic leucine zipper kinase, hMELK, 2.7.11.1, Protein kinase Eg3, pEg3 kinase, Protein kinase PK38, hPK38, Tyrosine-protein kinase MELK, 2.7.10.2, MELK, KIAA0175 |
| Name | MELK |
|---|---|
| Synonyms | KIAA0175 |
| Function | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. |
| Cellular Location | Cell membrane; Peripheral membrane protein |
| Tissue Location | Expressed in placenta, kidney, thymus, testis, ovary and intestine. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1341
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