KD-Validated Anti-Nth Like DNA Glycosylase 1 Rabbit Monoclonal Antibody

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18,000+ products cover the ten top research categories, including cancer, metabolism, cardiovascular, neuroscience, and stem cells. Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. Quality is embedded in the production process to assure the best antibody for you.

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Crown Products

Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications.

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New Products

Abgent develops 1000+ new products per year. We provide tools for path-breaking research by developing antibodies that detect a comprehensive library of novel and established targets. For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease.

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Current Promotion

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Research Focus

Greneral Collections

Peptides

SARS Peptides

Individual peptides for SARS-CoV-2 Spike glycoprotein. In order to study the specificity of cellular immune responses against SARS CoV-2 and potential immunity caused by other human Corona Viruses, Abcepta provides Spike peptide individually, as pools and in plate. These peptides can be used for antigen specific T-cell stimulation in T-cell assays or T-cell expansion.

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Synthetic Peptides

All peptides are manufactured in the San Diego, California. Custom peptide services include long peptides (>100 aa), cyclic peptides, difficult sequences, fluorescent labels, phospho-peptides and other post-translational modifications.

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Blocking Peptides

The majority of Abcepta antibodies are produced using peptide immunogens. These immuno-specific peptides can be used as blocking agents when using the complementary antibodies in a range of applications.

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Cell/Tissues/Lysates

Abcepta's portfolio of cell lines, tissues and lysates are drawn from a range of species and immortalized cell lines. All our cell lines and lysates are validated in key applications.

These tissue lysates can be used in applications such as SDS-PAGE and Western blotting. Whole cell lysates can be used as positive controls for applications such as ELISAs, immunoprecipitation (IP) and Western blotting. Obtaining high-quality whole cell lysates can be tedious as well as time consuming. Abcepta offers a comprehensive portfolio of whole cell lysates for research use. Browse our catalog to find the right whole cell lysate for your experiment.

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Citations

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

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Application Applications Legend: WB=Western Blot IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin-embedded Sections) IHC-F=Immunohistochemistry (Frozen Sections) IF=Immunofluorescence FC=Flow Cytopmetry IC=Immunochemistry ICC=Immunocytochemistry E=ELISA IP=Immunoprecipitation DB=Dot Blot CHIP=Chromatin Immunoprecipitation FA=Fluorescence Assay IEM=Immuno electron microscopy EIA=Enzyme Immunoassay	WB, FC, ICC
Primary Accession	P78549
Reactivity	Human
Clonality	Monoclonal
Isotype	Rabbit IgG
Clone Names	25GB3020
Calculated MW	Predicted, 34 kDa; observed, 34 kDa
Gene Name	NTHL1
Aliases	NTHL1; Nth Like DNA Glycosylase 1; OCTS3; NTH1; Bifunctional DNA N-Glycosylase/DNA-(Apurinic Or Apyrimidinic Site) Lyase; Endonuclease III-Like Protein 1; DNA Glycosylase/AP Lyase; HNTH1; Bifunctional DNA N-Glycoslyase/DNA-(Apurinic Or Apyrimidinic Site) Lyase; Nth Endonuclease III-Like 1 (E. Coli); Nth (E.Coli Endonuclease III)-Like 1; Nth Endonuclease III-Like 1; DNA Glycoslyase/AP Lyase; EC 4.2.99.18; EC 3.2.2.-; FAP3
Immunogen	A synthesized peptide derived from human NTH1

Gene ID	4913
Other Names	Endonuclease III-like protein 1 {ECO:0000255\|HAMAP-Rule:MF_03183}, hNTH1, 3.2.2.- {ECO:0000255\|HAMAP-Rule:MF_03183, ECO:0000269\|PubMed:9927729}, 4.2.99.18 {ECO:0000255\|HAMAP-Rule:MF_03183, ECO:0000269\|PubMed:9927729}, Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase {ECO:0000255\|HAMAP-Rule:MF_03183}, DNA glycosylase/AP lyase {ECO:0000255\|HAMAP-Rule:MF_03183}, NTHL1 {ECO:0000255\|HAMAP-Rule:MF_03183}, NTH1, OCTS3

Name	NTHL1 {ECO:0000255\|HAMAP-Rule:MF_03183}
Synonyms	NTH1, OCTS3
Function	Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:29610152, PubMed:9927729). The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta- elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Cellular Location	Nucleus {ECO:0000255\|HAMAP-Rule:MF_03183, ECO:0000269\|PubMed:10882850, ECO:0000269\|PubMed:12531031, ECO:0000269\|PubMed:9611236}. Mitochondrion {ECO:0000255\|HAMAP- Rule:MF_03183, ECO:0000269\|PubMed:9611236}
Tissue Location	Widely expressed with highest levels in heart and lowest levels in lung and liver.

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Rabbit monoclonal antibody

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