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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CGRP Receptor Component Rabbit Monoclonal Antibody
KD-Validated Anti-CGRP Receptor Component Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O75575 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3025 |
| Calculated MW | Predicted, 17 kDa; observed, 22 kDa |
| Gene Name | CRCP |
| Aliases | CRCP; CGRP Receptor Component; CGRP-RCP; Calcitonin Gene-Related Peptide-Receptor Component Protein; POLR3I; RCP9; RCP; C17; DNA-Directed RNA Polymerase III Subunit RPC9; CGRP-Receptor Component Protein; RNA Polymerase III Subunit C9; CGRPRCP; POLR3J; HsC17; RPC9 |
| Immunogen | A synthesized peptide derived from human CRCP |
| Gene ID | 27297 |
|---|---|
| Other Names | DNA-directed RNA polymerase III subunit RPC9, RNA polymerase III subunit C9, Calcitonin gene-related peptide-receptor component protein, CGRP-RCP, CGRP-receptor component protein, CGRPRCP, HsC17, CRCP (HGNC:17888) |
| Name | CRCP (HGNC:17888) |
|---|---|
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). |
| Cellular Location | Nucleus. Cell membrane {ECO:0000250|UniProtKB:O35427}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35427}; Cytoplasmic side {ECO:0000250|UniProtKB:O35427} |
| Tissue Location | Ubiquitous. Most prevalent in testis. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1345
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