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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Cytoplasmic linker associated protein 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Cytoplasmic linker associated protein 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q7Z460 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3810 |
| Calculated MW | Predicted, 169 kDa , observed, 169 kDa |
| Gene Name | CLASP1 |
| Aliases | CLASP1; Cytoplasmic Linker Associated Protein 1; MAST1; CLIP-Associating Protein 1; KIAA0622; Multiple Asters Homolog 1; Protein Orbit Homolog 1; Multiple Asters 1; Cytoplasmic Linker-Associated Protein 1; HOrbit1 |
| Immunogen | A synthesized peptide derived from human CLASP1 |
| Gene ID | 23332 |
|---|---|
| Other Names | CLIP-associating protein 1, Cytoplasmic linker-associated protein 1, Multiple asters homolog 1, Protein Orbit homolog 1, hOrbit1, CLASP1, KIAA0622, MAST1 |
| Name | CLASP1 |
|---|---|
| Synonyms | KIAA0622, MAST1 |
| Function | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2 |
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$ 149.00
$ 499.00
Cat# AGI1356
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