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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-ATP7B Rabbit Monoclonal Antibody
KD-Validated Anti-ATP7B Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P35670 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3945 |
| Calculated MW | Predicted, 157 kDa , observed, 157 kDa |
| Gene Name | ATP7B |
| Aliases | ATP7B; ATPase Copper Transporting Beta; Copper-Transporting ATPase 2; Copper Pump 2; WND; ATPase, Cu++ Transporting, Beta Polypeptide; Wilson Disease-Associated Protein; PWD; WC1; ATPase, Cu++ Transporting, Beta Polypeptide (Wilson Disease); ATPase, Cu(2+)- Transporting, Beta Polypeptide; Copper-Transporting Protein ATP7B; Wilson Disease; EC 7.2.2.8; EC 3.6.3.4; EC 3.6.3; WD |
| Immunogen | A synthesized peptide derived from human ATP7b |
| Gene ID | 540 |
|---|---|
| Other Names | Copper-transporting ATPase 2, 7.2.2.8, Copper pump 2, Wilson disease-associated protein, WND/140 kDa, ATP7B, PWD, WC1, WND |
| Name | ATP7B |
|---|---|
| Synonyms | PWD, WC1, WND |
| Function | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). [Isoform 2]: Cytoplasm |
| Tissue Location | Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1370
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