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> home > Products > Primary Antibodies > Antibody Collections > Head neck negative > KD-Validated Anti-SBDS Ribosome MatuRation Factor Rabbit Monoclonal Antibody
KD-Validated Anti-SBDS Ribosome MatuRation Factor Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9Y3A5 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3180 |
| Calculated MW | Predicted, 29 kDa; observed, 29 kDa |
| Gene Name | SBDS |
| Aliases | SBDS; SBDS Ribosome Maturation Factor; CGI-97; SWDS; SDO1; SDS; SBDS, Ribosome Assembly Guanine Nucleotide Exchange Factor; Ribosome Maturation Protein SBDS; FLJ10917; Shwachman-Bodian-Diamond Syndrome Protein; Shwachman-Bodian-Diamond Syndrome |
| Immunogen | A synthesized peptide derived from human SBDS |
| Gene ID | 51119 |
|---|---|
| Other Names | Ribosome maturation protein SBDS, Shwachman-Bodian-Diamond syndrome protein, SBDS |
| Name | SBDS |
|---|---|
| Function | Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. |
| Cellular Location | Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:17475909, PubMed:19602484). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). |
| Tissue Location | Widely expressed. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1373
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