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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Regulator Of Chromosome Condensation 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Regulator Of Chromosome Condensation 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P18754 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3350 |
| Calculated MW | Predicted, 45 kDa; observed, 48 kDa |
| Gene Name | RCC1 |
| Aliases | RCC1; Regulator Of Chromosome Condensation 1; CHC1; Regulator Of Chromosome Condensation; Cell Cycle Regulatory Protein; Guanine Nucleotide-Releasing Protein; Chromosome Condensation Protein 1; Chromosome Condensation 1; RCC1-I |
| Immunogen | A synthesized peptide derived from human RCC1 |
| Gene ID | 1104 |
|---|---|
| Other Names | Regulator of chromosome condensation, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, CHC1 |
| Name | RCC1 |
|---|---|
| Synonyms | CHC1 |
| Function | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). |
| Cellular Location | Nucleus. Chromosome. Cytoplasm Note=Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1394
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