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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-SMARCC1 Rabbit Monoclonal Antibody
KD-Validated Anti-SMARCC1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q92922 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4165 |
| Calculated MW | Predicted, 123 kDa , Observed, 155 kDa |
| Gene Name | SMARCC1 |
| Aliases | SMARCC1; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 1; BAF155; CRACC1; SRG3; SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily C Member 1; SWI/SNF Complex Subunit SMARCC1; SWI/SNF Complex 155 KDa Subunit; BRG1-Associated Factor 155; Rsc8; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of; Chromatin, Subfamily C, Member 1; Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 155; Chromatin Remodeling Complex BAF155 Subunit; HYC5; SWI3; RSC8 |
| Immunogen | A synthesized peptide derived from human SMARCC1/BAF155 |
| Gene ID | 6599 |
|---|---|
| Other Names | SWI/SNF complex subunit SMARCC1, BRG1-associated factor 155, BAF155, SWI/SNF complex 155 kDa subunit, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1, SMARCC1 (HGNC:11104), BAF155 |
| Name | SMARCC1 (HGNC:11104) |
|---|---|
| Synonyms | BAF155 |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1404
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