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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-RCHY1 Rabbit Monoclonal Antibody
KD-Validated Anti-RCHY1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q96PM5 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3545 |
| Calculated MW | Predicted, 30 kDa; observed, 26 kDa |
| Gene Name | RCHY1 |
| Aliases | RCHY1; Ring Finger And CHY Zinc Finger Domain Containing 1; RNF199; ZNF363; CHIMP; ARNIP; PIRH2; PRO1996; ZCHY; RING Finger And CHY Zinc Finger Domain-Containing Protein 1; Androgen-Receptor N-Terminal-Interacting Protein; P53-Induced Protein With A RING-H2 Domain; RING-Type E3 Ubiquitin Transferase RCHY1; E3 Ubiquitin-Protein Ligase Pirh2; RING Finger Protein 199; Zinc Finger Protein 363; Zinc Finger, CHY-Type; DKFZp586C1620; Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase; Androgen Receptor N-Terminal-Interacting Protein; CH-Rich Interacting Match With PLAG1; CH-Rich-Interacting Match With PLAG1; P53-Induced RING-H2 Protein; EC 2.3.2.27; HPirh2 |
| Immunogen | A synthesized peptide derived from human RCHY1 |
| Gene ID | 25898 |
|---|---|
| Other Names | RING finger and CHY zinc finger domain-containing protein 1, 2.3.2.27, Androgen receptor N-terminal-interacting protein, CH-rich-interacting match with PLAG1, E3 ubiquitin-protein ligase Pirh2, RING finger protein 199, RING-type E3 ubiquitin transferase RCHY1, Zinc finger protein 363, p53-induced RING-H2 protein, hPirh2, RCHY1 |
| Name | RCHY1 |
|---|---|
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19043414, PubMed:19483087). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). |
| Cellular Location | Nucleus. Nucleus speckle. Cytoplasm |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1430
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