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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-AKT3 Mouse Monoclonal Antibody
KD-Validated Anti-AKT3 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9Y243 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG3 |
| Clone Names | 25GB3680 |
| Calculated MW | Predicted, 56 kDa; observed, 56 kDa |
| Gene Name | AKT3 |
| Aliases | AKT3; AKT Serine/Threonine Kinase 3; PKBG; RAC-Gamma; PRKBG; RAC-Gamma Serine/Threonine-Protein Kinase; RAC-PK-Gamma; EC 2.7.11.1; PKB Gamma; STK-2; V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma); V-Akt Murine Thymoma Viral Oncogene Homolog 3; RAC-Gamma Serine/Threonine Protein Kinase; Protein Kinase B, Gamma; Protein Kinase B Gamma; Protein Kinase Akt-3; PKB-GAMMA; EC 2.7.11; MPPH2; MPPH |
| Immunogen | Recombinant protein of human AKT3 |
| Gene ID | 10000 |
|---|---|
| Other Names | RAC-gamma serine/threonine-protein kinase, 2.7.11.1, Protein kinase Akt-3, Protein kinase B gamma, PKB gamma, RAC-PK-gamma, STK-2, AKT3, PKBG |
| Name | AKT3 |
|---|---|
| Synonyms | PKBG |
| Function | AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down- regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. |
| Cellular Location | Nucleus. Cytoplasm. Membrane; Peripheral membrane protein Note=Membrane-associated after cell stimulation leading to its translocation |
| Tissue Location | In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1441
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