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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Nesprin3 Rabbit Monoclonal Antibody
KD-Validated Anti-Nesprin3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q6ZMZ3 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4670 |
| Calculated MW | Predicted, 112 kDa, observed, 100 kDa |
| Gene Name | SYNE3 |
| Aliases | SYNE3; Spectrin Repeat Containing Nuclear Envelope Family Member 3; Nesprin-3; LINC00341; NET53; Long Intergenic Non-Protein Coding RNA 341; Nuclear Envelope Spectrin Repeat Protein 3; KASH Domain-Containing Protein 3; NCRNA00341; C14orf139; FLJ25605; C14orf49; Nesp3; KASH3; Chromosome 14 Open Reading Frame 139; Chromosome 14 Open Reading Frame 49; Uncharacterized Protein C14orf113; Non-Protein Coding RNA 341; C14ORF139; NESPRIN-3; C14ORF49; NESP3 |
| Immunogen | A synthesized peptide derived from human Nesprin3 |
| Gene ID | 161176 |
|---|---|
| Other Names | Nesprin-3, KASH domain-containing protein 3, KASH3, Nuclear envelope spectrin repeat protein 3, SYNE3 (HGNC:19861) |
| Name | SYNE3 (HGNC:19861) |
|---|---|
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. |
| Cellular Location | Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum |
| Tissue Location | Expressed in aortic endothelial cells (at protein level). |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1465
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