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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Thyroid hormone receptor interactor 10 Rabbit Monoclonal Antibody
KD-Validated Anti-Thyroid hormone receptor interactor 10 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q15642 |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4705 |
| Calculated MW | Predicted, 68 kDa, observed, 75 kDa |
| Gene Name | TRIP10 |
| Aliases | TRIP10; Thyroid Hormone Receptor Interactor 10; HSTP; CIP4; STP; STOT; Thyroid Receptor-Interacting Protein 10; Cdc42-Interacting Protein 4; TR-Interacting Protein 10; Salt Tolerant Protein; Salt Tolerator; Protein Felic; TRIP-10; Cdc42-Interacting Protein |
| Immunogen | A synthesized peptide derived from human Cip4 |
| Gene ID | 9322 |
|---|---|
| Other Names | Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, hSTP, Thyroid receptor-interacting protein 10, TR-interacting protein 10, TRIP-10, TRIP10, CIP4, STOT, STP |
| Name | TRIP10 |
|---|---|
| Synonyms | CIP4, STOT, STP |
| Function | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte- derived cells. May be required for the lysosomal retention of FASLG/FASL. |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity) Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. |
| Tissue Location | Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. |
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$ 149.00
$ 499.00
Cat# AGI1468
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