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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Adenylate kinase 4 Rabbit Monoclonal Antibody
KD-Validated Anti-Adenylate kinase 4 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P27144 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4755 |
| Calculated MW | Predicted, 25 kDa , observed, 25 kDa |
| Gene Name | AK4 |
| Aliases | AK4; Adenylate Kinase 4; AK3L1; AK3; Adenylate Kinase 4, Mitochondrial; Adenylate Kinase 3-Like 1; AK 4; GTP:AMP Phosphotransferase AK4, Mitochondrial; Adenylate Kinase Isoenzyme 4, Mitochondrial; Epididymis Secretory Sperm Binding Protein; Nucleoside-Triphosphate-Adenylate Kinase; Mitochondrial Adenylate Kinase-3; GTP:AMP Phosphotransferase AK4; ATP-AMP Transphosphorylase; Adenylate Kinase 3-Like; Adenylate Kinase 3; EC 2.7.4.10; EC 2.7.4.6; EC 2.7.4.3; EC 2.7.4; AK3L2 |
| Immunogen | A synthesized peptide derived from human Adenylate kinase 4 |
| Gene ID | 205 |
|---|---|
| Other Names | Adenylate kinase 4, mitochondrial, 2.7.4.4, 2.7.4.6, Adenylate kinase 3-like {ECO:0000255|HAMAP-Rule:MF_03170}, GTP:AMP phosphotransferase AK4 {ECO:0000255|HAMAP-Rule:MF_03170}, AK4 (HGNC:363) |
| Name | AK4 (HGNC:363) |
|---|---|
| Function | Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside- phosphate interconversions (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP (PubMed:19766732). Phosphorylates only AMP when using GTP as phosphate donor (PubMed:19766732). In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor (PubMed:19766732, PubMed:23416111). Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors (PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435). |
| Cellular Location | Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:26980435} |
| Tissue Location | Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain |
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$ 149.00
$ 499.00
Cat# AGI1496
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