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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Drosha ribonuclease III Rabbit Monoclonal Antibody
KD-Validated Anti-Drosha ribonuclease III Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9NRR4 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5205 |
| Calculated MW | Predicted, 159 kDa , observed, 159 kDa |
| Gene Name | DROSHA |
| Aliases | DROSHA; Drosha Ribonuclease III; RNASE3L; RN3; HSA242976; RNASEN; Drosha, Double-Stranded RNA-Specific Endoribonuclease; Ribonuclease Type III, Nuclear; Ribonuclease 3; EC 3.1.26.3; RNase III; ETOHI2; P241; Putative Protein P241 Which Interacts With Transcription Factor Sp1; Drosha, Ribonuclease Type III; Putative Ribonuclease III; Nuclear RNase III Drosha; Ribonuclease III; Protein Drosha; RANSE3L; Etohi2 |
| Immunogen | A synthesized peptide derived from human Drosha |
| Gene ID | 29102 |
|---|---|
| Other Names | Ribonuclease 3, 3.1.26.3, Protein Drosha, Ribonuclease III, RNase III, p241, DROSHA, RN3, RNASE3L, RNASEN |
| Name | DROSHA |
|---|---|
| Synonyms | RN3, RNASE3L, RNASEN |
| Function | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri- miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). |
| Cellular Location | Nucleus. Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q5HZJ0}. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. |
| Tissue Location | Ubiquitous.. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1506
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