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KD-Validated Anti-Desmoglein 2 Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
  • WB - KD-Validated Anti-Desmoglein 2 Rabbit Monoclonal Antibody AGI1508
    Western blotting analysis using anti-Desmoglein 2 antibody (Cat#61939). Total cell lysates (30 µg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-Desmoglein 2 antibody (Cat#61939, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226).
    detail
  • WB - KD-Validated Anti-Desmoglein 2 Rabbit Monoclonal Antibody AGI1508
    Western blotting analysis using anti-Desmoglein 2 antibody (Cat#61939). Desmoglein 2 expression in wild type (WT) and Desmoglein 2 shRNA knockdown (KD) HeLa cells with 30 µg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-Desmoglein 2 antibody (Cat#61939, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226).
    detail
  • FC - KD-Validated Anti-Desmoglein 2 Rabbit Monoclonal Antibody AGI1508
    Flow cytometric analysis of Desmoglein 2 expression in HepG2 cells using Desmoglein 2 antibody (Cat#61939, 1:2,000). Green, isotype control; red, Desmoglein 2.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC
Primary Accession Q14126
Reactivity Human
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 23GB5215
Calculated MW Predicted, 122 kDa , observed, 160 kDa
Gene Name DSG2
Aliases DSG2; Desmoglein 2; CDHF5; Cadherin Family Member 5; Desmoglein-2; HDGC
Immunogen A synthesized peptide derived from human Desmoglein 2
Additional Information
Gene ID 1829
Other Names Desmoglein-2, Cadherin family member 5, HDGC, DSG2, CDHF5
Protein Information
Name DSG2
Synonyms CDHF5
Function A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Cytoplasm
Tissue Location Expressed in undifferentiated pluripotent stem cells, expression decreases during differentiation (at protein level) (PubMed:29910125). Expressed in hematopoietic stem cells and circulating endothelial progenitor cells, expression decreases upon increasing cell lineage commitment (at protein level) (PubMed:27338829). Expressed on common myeloid progenitors, pro- myelocytes, pro-erythrocytes and B-cell linage progenitors (at protein level). Expression in mature cell types in the bone marrow and mature leukocyte populations is absent (PubMed:27338829). Expressed by foreskin fibroblasts, expression peaks during the early stage of differentiation reprogramming (at protein level) (PubMed:29910125) Expressed by endothelial cells in both arterioles and venules in the cervix (at protein level) (PubMed:27338829). Expressed in kidney tubular epithelial cells (PubMed:38395410)
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$ 149.00
$ 499.00
Cat# AGI1508
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