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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Ephrin A1 Rabbit Monoclonal Antibody
KD-Validated Anti-Ephrin A1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P20827 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5265 |
| Calculated MW | Predicted, 24 kDa , o bserved , 24 kDa |
| Gene Name | EFNA1 |
| Aliases | EFNA1; Ephrin A1; LERK1; Ephrin-A1; TNFAIP4; ECKLG; EPLG1; GMAN ; Gastric Cancer Metastasis Associated Long Noncoding RNA; EPH-Related Receptor Tyrosine Kinase Ligand 1; Tumor Necrosis Factor Alpha-Induced Protein 4; Immediate Early Response Protein B61; TNF Alpha-Induced Protein 4; LERK-1; Tumor Necrosis Factor, Alpha-Induced Protein 4; Eph-Related Receptor Tyrosine Kinase Ligand 1; Epididymis Secretory Sperm Binding Protein; Ligand Of Eph-Related Kinase 1; EFL1; B61 |
| Immunogen | A synthesized peptide derived from human Ephrin A1 |
| Gene ID | 1942 |
|---|---|
| Other Names | Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, TNF alpha-induced protein 4, Ephrin-A1, secreted form, EFNA1, EPLG1, LERK1, TNFAIP4 |
| Name | EFNA1 |
|---|---|
| Synonyms | EPLG1, LERK1, TNFAIP4 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down- regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down- regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
| Tissue Location | Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1514
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