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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-GARS Rabbit Monoclonal Antibody
KD-Validated Anti-GARS Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P41250 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5515 |
| Calculated MW | Predicted, 83 kDa, observed, 75 kDa |
| Gene Name | GARS1 |
| Aliases | GARS1; Glycyl-TRNA Synthetase 1; GlyRS; DSMAV; SMAD1; GARS; Diadenosine Tetraphosphate Synthetase; Charcot-Marie-Tooth Neuropathy 2D; Glycyl-TRNA Synthetase; Glycine--TRNA Ligase; Ap4A Synthetase; EC 6.1.1.14; CMT2D; Charcot-Marie-Tooth Neuropathy, Neuronal Type, D; Glycine TRNA Ligase; AP-4-A Synthetase; EC 2.7.7.-; HMN5A; SMAJI; GLYRS; HMN5 |
| Immunogen | A synthesized peptide derived from human GARS |
| Gene ID | 2617 |
|---|---|
| Other Names | Glycine--tRNA ligase, 6.1.1.14, Diadenosine tetraphosphate synthetase, Ap4A synthetase, 2.7.7.-, Glycyl-tRNA synthetase, GlyRS, Glycyl-tRNA synthetase 1 {ECO:0000312|HGNC:HGNC:4162}, GARS1 (HGNC:4162), GARS |
| Name | GARS1 (HGNC:4162) |
|---|---|
| Synonyms | GARS |
| Function | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). |
| Cellular Location | Cytoplasm. Cell projection, axon. Secreted {ECO:0000250|UniProtKB:Q9CZD3}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q9CZD3}. Note=In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524) Secreted by motor neuron, possibly through the exosome pathway (By similarity). {ECO:0000250|UniProtKB:Q9CZD3, ECO:0000269|PubMed:17035524} [Isoform 2]: Cytoplasm. Cell projection, axon |
| Tissue Location | Widely expressed, including in brain and spinal cord. [Isoform 1]: Expressed in brain, spinal cord, muscle, heart, spleen and liver. |
Research Areas
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$ 399.20
$ 149.00
Cat# AGI1521
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