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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-HuR / ELAVL1 Rabbit Monoclonal Antibody
KD-Validated Anti-HuR / ELAVL1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q15717 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5815 |
| Calculated MW | Predicted, 36 kDa, observed, 30 kDa |
| Gene Name | ELAVL1 |
| Aliases | ELAVL1; ELAV Like RNA Binding Protein 1; HUR; ELAV (Embryonic Lethal, Antibodynormal Vision, Drosophila)-Like 1 (Hu Antigen R); Embryonic Lethal, Antibodynormal Vision, Drosophila, Homolog-Like 1; ELAV-Like Protein 1; Hu Antigen R; Hu-Antigen R; MelG; HuR; Hua; ELAV1; MELG; HUA |
| Immunogen | A synthesized peptide derived from human HuR / ELAVL1 |
| Gene ID | 1994 |
|---|---|
| Other Names | ELAV-like protein 1, Hu-antigen R, HuR, ELAVL1, HUR |
| Name | ELAVL1 |
|---|---|
| Synonyms | HUR |
| Function | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P70372}. Cytoplasm, P-body. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462). Localizes to the stress granules in the presence of PLEKHN1 (By similarity). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:18285462} |
| Tissue Location | Ubiquitous. Detected in brain, liver, thymus and muscle. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1542
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