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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-GEMIN2 Rabbit Monoclonal Antibody
KD-Validated Anti-GEMIN2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O14893 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5835 |
| Calculated MW | Predicted, 32 kDa , observed , 31 kDa |
| Gene Name | GEMIN2 |
| Aliases | GEMIN2; Gem Nuclear Organelle Associated Protein 2; SIP1; Survival Of Motor Neuron Protein Interacting Protein 1; Gem-Associated Protein; Component Of Gems; Gemin-2; Survival Of Motor Neuron Protein-Interacting Protein 1; Gem (Nuclear Organelle) Associated Protein 2; SMN Interacting Protein 1-Delta; SMN-Interacting Protein 1; SIP1-Delta |
| Immunogen | A synthesized peptide derived from human Gemin 2 |
| Gene ID | 8487 |
|---|---|
| Other Names | Gem-associated protein 2, Gemin-2, Component of gems 2, Survival of motor neuron protein-interacting protein 1, SMN-interacting protein 1, GEMIN2 (HGNC:10884), SIP1 |
| Name | GEMIN2 (HGNC:10884) |
|---|---|
| Synonyms | SIP1 |
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). |
| Cellular Location | Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1543
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