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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-GOPC Rabbit Monoclonal Antibody
KD-Validated Anti-GOPC Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9HD26 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5870 |
| Calculated MW | Predicted, 51 kDa , observed , 51 kDa |
| Gene Name | GOPC |
| Aliases | GOPC; Golgi Associated PDZ And Coiled-Coil Motif Containing; PIST; FIG; CAL; DJ94G16.2; GOPC1; Golgi-Associated PDZ And Coiled-Coil Motif-Containing Protein; PDZ Protein Interacting Specifically With TC10; CFTR-Associated Ligand; Fused In Glioblastoma; PDZ/Coiled-Coil Domain Binding Partner For The Rho-Family GTPase TC10; Golgi-Associated PDZ And Coiled-Coil Motif Containing Protein; DJ94G16.2 PIST |
| Immunogen | A synthesized peptide derived from human PIST |
| Gene ID | 57120 |
|---|---|
| Other Names | Golgi-associated PDZ and coiled-coil motif-containing protein {ECO:0000312|HGNC:HGNC:17643}, CFTR-associated ligand, Fused in glioblastoma, PDZ protein interacting specifically with TC10, PIST, GOPC (HGNC:17643) |
| Name | GOPC (HGNC:17643) |
|---|---|
| Function | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). |
| Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. |
| Tissue Location | Ubiquitously expressed. |
Research Areas
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$ 399.20
$ 149.00
Cat# AGI1544
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