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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-GTF2I Rabbit Monoclonal Antibody
KD-Validated Anti-GTF2I Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P78347 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5950 |
| Calculated MW | Predicted, 113 kDa , observed , 135 kDa |
| Gene Name | GTF2I |
| Aliases | GTF2I; General Transcription Factor IIi; TFII-I; SPIN; BAP-135; BTKAP1; WBSCR6; IB291; DIWS; Bruton Tyrosine Kinase-Associated Protein 135; General Transcription Factor II-I; SRF-Phox1-Interacting Protein; GTFII-I; BAP135; Williams-Beuren Syndrome Chromosomal Region 6 Protein; Williams-Beuren Syndrome Chromosome Region 6; General Transcription Factor II, I; BTK-Associated Protein, 135kD; BTK-Associated Protein 135; WBS |
| Immunogen | A synthesized peptide derived from human GTF2I |
| Gene ID | 2969 |
|---|---|
| Other Names | General transcription factor II-I, GTFII-I, TFII-I, Bruton tyrosine kinase-associated protein 135, BAP-135, BTK-associated protein 135, SRF-Phox1-interacting protein, SPIN, Williams-Beuren syndrome chromosomal region 6 protein, GTF2I, BAP135, WBSCR6 |
| Name | GTF2I |
|---|---|
| Synonyms | BAP135, WBSCR6 |
| Function | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA- binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551} Note=Colocalizes with BTK in the cytoplasm |
| Tissue Location | Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1545
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