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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CDC42 Rabbit Monoclonal Antibody
KD-Validated Anti-CDC42 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P60953 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB1025 |
| Calculated MW | Predicted , 21 kDa , observed , 21 kDa |
| Gene Name | CDC42 |
| Aliases | CDC42; Cell Division Cycle 42; Cell Division Control Protein 42 Homolog; G25K GTP-Binding Protein; DJ224A6.1.1 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD)); 25kDa; DJ224A6.1.2 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD)); Cell Division Cycle 42 (GTP Binding Protein, 25kDa); Growth-Regulating Protein; Cell Division Cycle 42 (GTP-Binding Protein, 25kD); GTP Binding Protein; 25kDa; GTP Binding Protein; GTP-Binding Protein; 25kD; CDC42Hs; Small GTP Binding Protein CDC42; G25K |
| Immunogen | Recombinant protein of human CDC42 |
| Gene ID | 998 |
|---|---|
| Other Names | Cell division control protein 42 homolog, 3.6.5.2, G25K GTP-binding protein, CDC42 (HGNC:1736) |
| Name | CDC42 (HGNC:1736) |
|---|---|
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317, PubMed:22843693). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation (PubMed:33523862). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210). Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation (PubMed:33310911). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody Cell projection, dendrite {ECO:0000250|UniProtKB:P60766} Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase (PubMed:15642749). Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (PubMed:15642749). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1 (PubMed:15642749). Colocalizes with NEK6 in the centrosome (PubMed:20873783). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (By similarity) {ECO:0000250|UniProtKB:P60766, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:20873783} |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1555
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