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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-KSR1 Rabbit Monoclonal Antibody
KD-Validated Anti-KSR1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q8IVT5 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB6290 |
| Calculated MW | Predicted, 102 kDa , observed , 120 kDa |
| Gene Name | KSR1 |
| Aliases | KSR1; Kinase Suppressor Of Ras 1; RSU2; KSR; Kinase Suppressor Of Ras; EC 2.7.11.1 |
| Immunogen | A synthesized peptide derived from human KSR1 |
| Gene ID | 8844 |
|---|---|
| Other Names | Kinase suppressor of Ras 1, 2.7.11.1, KSR1, KSR |
| Name | KSR1 |
|---|---|
| Synonyms | KSR |
| Function | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q61097}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61097}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61097}. Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. |
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Application Protocols
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$ 399.20
$ 149.00
Cat# AGI1561
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