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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-MAP Kinase Activating Death Domain Rabbit Monoclonal Antibody
KD-Validated Anti-MAP Kinase Activating Death Domain Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q8WXG6 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB110 |
| Calculated MW | Predicted, 183 kDa, observed , 230 kDa |
| Gene Name | MADD |
| Aliases | MAP Kinase Activating Death Domain; DENN; Differentially Expressed In Normal And Neoplastic Cells; KIAA0358; RAB3GEP; IG20; MAP Kinase-Activating Death Domain Protein; Insuloma-Glucagonoma Protein 20; Insulinoma Glucagonoma Clone 20; Rab3 GDP/GTP Exchange Protein; Rab3 GDP/GTP Exchange Factor; RabGEF; MAP-Kinase Activating Death Domain; NEDDISH; Rab3GEP; DEEAH |
| Immunogen | A synthesized peptide derived from human DENN |
| Gene ID | 8567 |
|---|---|
| Other Names | MAP kinase-activating death domain protein, Differentially expressed in normal and neoplastic cells, Insulinoma glucagonoma clone 20, Rab3 GDP/GTP exchange factor, RabGEF, Rab3 GDP/GTP exchange protein, Rab3GEP, MADD {ECO:0000312|EMBL:AAB57735.1, ECO:0000312|HGNC:HGNC:6766} |
| Name | MADD {ECO:0000312|EMBL:AAB57735.1, ECO:0000312|HGNC:HGNC:6766} |
|---|---|
| Function | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A- positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). |
| Cellular Location | Cell membrane. Cytoplasm. Cell projection, axon {ECO:0000250|UniProtKB:Q80U28} |
| Tissue Location | Expressed in testis, ovary, brain and heart (PubMed:8988362). Expressed in spleen, thymus, prostate, testis, ovary, small instestine and colon (PubMed:9115275). Expressed in liver (PubMed:9796103). [Isoform 2]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid [Isoform 4]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid [Isoform 6]: Not detected in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1587
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