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> home > Products > Primary Antibodies > Antibody Collections > SARS-Human interaction partners > KD-Validated Anti-MYD88 Rabbit Monoclonal Antibody
KD-Validated Anti-MYD88 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q99836 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB240 |
| Calculated MW | Predicted, 33 kDa, Observed , 33 kDa |
| Gene Name | MYD88 |
| Aliases | MYD88 Innate Immune Signal Transduction Adaptor; Myeloid Differentiation Primary Response Protein MyD88; Myeloid Differentiation Primary Response Gene (88); Myeloid Differentiation Primary Response 88; TLR Adaptor MYD88; Mutant Myeloid Differentiation Primary Response 88; MYD88D; IMD68; WM1 |
| Immunogen | A synthesized peptide derived from human MyD88 |
| Gene ID | 4615 |
|---|---|
| Other Names | Myeloid differentiation primary response protein MyD88, MYD88 (HGNC:7562) |
| Name | MYD88 (HGNC:7562) |
|---|---|
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825, PubMed:37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:19506249, PubMed:24316379). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU- rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitous.. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI1591
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