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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-DGCR8 Rabbit Monoclonal Antibody
KD-Validated Anti-DGCR8 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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Application 
| WB, ICC |
|---|---|
| Primary Accession | Q8WYQ5 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB1615 |
| Calculated MW | Predicted, 86 kDa , observed, 110 kDa |
| Gene Name | DGCR8 |
| Aliases | DGCR8; DGCR8 Microprocessor Complex Subunit; DGCRK6; DiGeorge Syndrome Critical Region Gene 8; Microprocessor Complex Subunit DGCR8; DiGeorge Syndrome Critical Region 8; C22orf12; Pasha; Gy1; DGCR8, Microprocessor Complex Subunit; Chromosome 22 Open Reading Frame 12; C22ORF12; PASHA; GY1 |
| Immunogen | A synthesized peptide derived from human DGCR8 |
| Gene ID | 54487 |
|---|---|
| Other Names | Microprocessor complex subunit DGCR8, DiGeorge syndrome critical region 8, DGCR8, C22orf12, DGCRK6 |
| Name | DGCR8 |
|---|---|
| Synonyms | C22orf12, DGCRK6 |
| Function | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme- bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double- strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). |
| Cellular Location | Nucleus. Nucleus, nucleolus. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994) |
| Tissue Location | Ubiquitously expressed. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1595
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