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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Methyl-CpG Binding Domain Protein 2 Rabbit Monoclonal Antibody
KD-Validated Anti-Methyl-CpG Binding Domain Protein 2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9UBB5 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB460 |
| Calculated MW | Predicted, 43 kDa , observed , 29,43 kDa |
| Gene Name | MBD2 |
| Aliases | MBD2; Methyl-CpG Binding Domain Protein 2; Methyl-CpG-Binding Domain Protein 2; Demethylase; DMTase; Methyl-CpG-Binding Protein MBD2; NY-CO-41 |
| Immunogen | A synthesized peptide derived from human MBD2 |
| Gene ID | 8932 |
|---|---|
| Other Names | Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2, MBD2 (HGNC:6917) |
| Name | MBD2 (HGNC:6917) |
|---|---|
| Function | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). |
| Cellular Location | Nucleus. Chromosome Note=Nuclear, in discrete foci (PubMed:12183469). Detected at replication foci in late S phase. Localizes to methylated chromatin (PubMed:16428440). Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 (PubMed:27732854) |
| Tissue Location | Highly expressed in brain, heart, kidney, stomach, testis and placenta. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1606
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