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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-RalA Binding Protein 1 Rabbit Monoclonal Antibody
KD-Validated Anti-RalA Binding Protein 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q15311 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB875 |
| Calculated MW | Predicted, 76 kDa , observed , 95 kDa |
| Gene Name | RALBP1 |
| Aliases | RalA Binding Protein 1; RLIP76; RIP1; Dinitrophenyl S-Glutathione ATPase; 76 KDa Ral-Interacting Protein; Ral-Interacting Protein 1; RalA-Binding Protein 1; DNP-SG ATPase; RLIP1; RIP; EC 7.6.2.2; EC 7.6.2.3; RalBP1; RLIP |
| Immunogen | A synthesized peptide derived from human RALBP1 |
| Gene ID | 10928 |
|---|---|
| Other Names | RalA-binding protein 1, 76 kDa Ral-interacting protein, Dinitrophenyl S-glutathione ATPase, DNP-SG ATPase, 7.6.2.2, 7.6.2.3, Ral-interacting protein 1, RALBP1 (HGNC:9841) |
| Name | RALBP1 (HGNC:9841) |
|---|---|
| Function | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). |
| Cellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q62796} Nucleus. Mitochondrion. Note=Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity) Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity). Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277). Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells (PubMed:22319010). The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (Probable) {ECO:0000250|UniProtKB:Q62796, ECO:0000250|UniProtKB:Q9PT60, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:22319010, ECO:0000305|PubMed:15610018} |
| Tissue Location | Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1632
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