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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Ring Finger Protein 40 Rabbit Monoclonal Antibody
KD-Validated Anti-Ring Finger Protein 40 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | O75150 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1100 |
| Calculated MW | Predicted, 114 kDa , observed , 130 kDa |
| Gene Name | RNF40 |
| Aliases | Ring Finger Protein 40; RBP95; BRE1B; KIAA0661; STARING; 95 KDa Retinoblastoma-Associated Protein; RING-Type E3 Ubiquitin Transferase BRE1B; E3 Ubiquitin-Protein Ligase BRE1B; BRE1-B; Ring Finger Protein 40, E3 Ubiquitin Protein Ligase; BRE1 E3 Ubiquitin Ligase Homolog B (S. Cerevisiae); 95 KDa Retinoblastoma Protein Binding Protein; BRE1 E3 Ubiquitin Ligase Homolog B; RING Finger Protein 40; Rb-Associated Protein; EC 2.3.2.27; EC 6.3.2 |
| Immunogen | A synthesized peptide derived from human RNF40 |
| Gene ID | 9810 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase BRE1B, BRE1-B, 2.3.2.27, 95 kDa retinoblastoma-associated protein, RBP95, RING finger protein 40, RING-type E3 ubiquitin transferase BRE1B, RNF40, BRE1B, KIAA0661 |
| Name | RNF40 |
|---|---|
| Synonyms | BRE1B, KIAA0661 |
| Function | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1653
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