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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-PIK3C3 Rabbit Monoclonal Antibody
KD-Validated Anti-PIK3C3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q8NEB9 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1150 |
| Calculated MW | Predicted, 102 kDa , observed , 100 kDa |
| Gene Name | PIK3C3 |
| Aliases | Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3; HVps34; Vps34; Phosphatidylinositol 3-Kinase P100 Subunit; Vacuolar Protein Sorting 34 Homolog; Phosphoinositide-3-Kinase, Class 3; PtdIns-3-Kinase Type 3; PI3-Kinase Type 3; EC 2.7.1.137; PI3K Type 3; Phosphatidylinositol 3-Kinase, Catalytic Subunit Type 3; Phosphoinositide-3-Kinase Class 3; EC 2.7.1; VPS34 |
| Immunogen | A synthesized peptide derived from human PI 3 Kinase Class 3 |
| Gene ID | 5289 |
|---|---|
| Other Names | Phosphatidylinositol 3-kinase catalytic subunit type 3, PI3-kinase type 3, PI3K type 3, PtdIns-3-kinase type 3, 2.7.1.137, Phosphatidylinositol 3-kinase p100 subunit, Phosphoinositide-3-kinase class 3, hVps34, PIK3C3 (HGNC:8974), VPS34 {ECO:0000305} |
| Name | PIK3C3 (HGNC:8974) |
|---|---|
| Synonyms | VPS34 {ECO:0000305} |
| Function | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). |
| Cellular Location | Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity) {ECO:0000250|UniProtKB:Q6PF93, ECO:0000305|PubMed:14617358} |
| Tissue Location | Ubiquitously expressed, with a highest expression in skeletal muscle. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1656
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