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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Peptidylprolyl Isomerase D Rabbit Monoclonal Antibody
KD-Validated Anti-Peptidylprolyl Isomerase D Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q08752 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1560 |
| Calculated MW | Predicted, 41 kDa , observed, 36 kDa |
| Gene Name | PPID |
| Aliases | Peptidylprolyl Isomerase D; CYP-40; CypD; Peptidyl-Prolyl Cis-Trans Isomerase D; Cyclophilin-Related Protein; Cyclophilin 40; Rotamase D; EC 5.2.1.8; PPIase D; 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase D; Peptidylprolyl Isomerase D (Cyclophilin D); 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase; Testicular Tissue Protein Li 147; Cyclophilin-40; Cyclophilin D; CYP40; CYPD |
| Immunogen | A synthesized peptide derived from human Cyclophilin 40 |
| Gene ID | 5481 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase D, PPIase D, 5.2.1.8, 40 kDa peptidyl-prolyl cis-trans isomerase, Cyclophilin-40, CYP-40, Cyclophilin-related protein, Rotamase D, PPID (HGNC:9257), CYP40, CYPD |
| Name | PPID (HGNC:9257) |
|---|---|
| Synonyms | CYP40, CYPD |
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co- chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone- receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. |
| Cellular Location | Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm |
| Tissue Location | Widely expressed. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1692
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